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・ Pha̍k-oa-chhi romanization
・ PHB
・ PHB (bicycle)
・ PHB2
・ PHBV
・ PHC
・ PHC Zebras
・ PHC1
・ PHC2
・ PHC3
・ PHCC
・ PHCCC
・ PHD
・ PhD confirmation
・ PhD Docbook renderer
PHD finger
・ PhD in management
・ PHD Mountain Software
・ PhD-MBA
・ PhDiA
・ PhDTree Project
・ PHE
・ Phe (disambiguation)
・ Pheak Rady
・ Phearath Nget
・ Pheasant
・ Pheasant (disambiguation)
・ Pheasant Breeding Centre Morni
・ Pheasant Breeding Centre, Berwala
・ Pheasant coucal


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PHD finger : ウィキペディア英語版
PHD finger

The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in ''Arabidopsis thaliana'' and maize ZmHox1a.
The PHD finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.
== PHD finger in proteins related to epigenetics ==
The PHD finger, approximately 50-80 amino acids in length, is found in more than 100 human proteins. Several of the proteins it occurs in are found in the nucleus, and are involved in chromatin-mediated gene regulation. The PHD finger occurs in proteins such as the transcriptional co-activators p300 and CBP, Polycomb-like protein (Pcl), Trithorax-group proteins like ASH1L, ASH2L and MLL, the autoimmune regulator (AIRE), Mi-2 complex (part of histone deacetylase complex), the co-repressor TIF1, the JARID1-family of demethylases and many more.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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